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Image Search Results
Journal: Frontiers in Pharmacology
Article Title: A Modified Compound From Paeoniflorin, CP-25, Suppressed Immune Responses and Synovium Inflammation in Collagen-Induced Arthritis Mice
doi: 10.3389/fphar.2018.00563
Figure Lengend Snippet: CP-25 down-regulated excessive synoviocyte activation by decreasing GRK2-mediated β2-AR desensitization. MH7A (A,B) proliferation (1 nM: t = 1.067, P < 0.05; 0.1 μM: t = 3.584, P < 0.01; 1 μM: t = 5.768, P < 0.01; 10 μM: t = 5.685, P < 0.01), (C,E) migration (0.1 μM: t = 5.268, P < 0.01; 1 μM: t = 6.141, P < 0.01; 10 μM: t = 6.070, P < 0.01), and (D,F) invasion (0.1 μM: t = 2.514, P < 0.05; 1 μM: t = 5.477, P < 0.01; 10 μM: t = 5.691, P < 0.01). Data are expressed as the mean ± SD. ## P < 0.01 vs. control; ∗ P < 0.05, ∗∗ P < 0.01 vs. TNF + ISO. The results are representative of at least three independent experiments. (G–I) Expression of β2-AR ( t = –12.745, P < 0.01) and GRK2 ( t = 5.986, P < 0.01). The results are representative of at least three independent experiments and data are expressed as the mean ± SD. ∗∗ P < 0.01 vs. TNF.
Article Snippet: The human RA fibroblast-like synoviocyte (FLS) cell line,
Techniques: Activation Assay, Migration, Control, Expressing
Journal: Materials & Design
Article Title: Hyaluronic acid methacrylate microneedles loaded with astaxanthin alleviate rheumatoid arthritis by downregulating the PI3K-AKT pathway
doi: 10.1016/j.matdes.2025.114571
Figure Lengend Snippet: Fig. 2. ATX inhibits proliferation, migration and invasion capabilities of MH7A cells. A: colony assay in different groups. B: migration assay in different groups. C: transwell assay in different groups. D: WB analysis of P-PI3K and P-AKT in different groups. *p < 0.05,**p < 0.01,***p < 0.001.
Article Snippet: For evaluating the biocompatibility of HAMA/ATX MNs, the cytoskeleton of
Techniques: Migration, Colony Assay, Transwell Assay
Journal: Materials & Design
Article Title: Hyaluronic acid methacrylate microneedles loaded with astaxanthin alleviate rheumatoid arthritis by downregulating the PI3K-AKT pathway
doi: 10.1016/j.matdes.2025.114571
Figure Lengend Snippet: Fig. 3. ATX inhibits MH7A cells proliferation, migration and invasion thriough PI3K-AKT pathway. A: colony assay in different groups. B: migration assay in different groups. C: transwell assay in different groups. D: WB analysis of P-PI3K and P-AKT in different groups. *p < 0.05,**p < 0.01,***p < 0.001.
Article Snippet: For evaluating the biocompatibility of HAMA/ATX MNs, the cytoskeleton of
Techniques: Migration, Colony Assay, Transwell Assay